A retrospective pharmacovigilance analysis based on the FAERS database reveals sex-associated differences in toxicities of CAR T-cell therapy
Leng Han
Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72816-8 Despite the proven therapeutic efficacy, CAR T cell treatment carries the risk of severe toxicities. How sex-associated differences affect therapy-associated toxicities is underexplored. Here, the authors conduct a retrospective pharmacovigilant study using the FAERS database and highlight sex-associated differences in CAR T therapy complications, with females exhibiting a consistent pattern of increased adverse