HDAC10 promotes Th17 differentiation and IL17Adriven neutrophilic airway inflammation in severe asthma

To delineate HDAC10’s function in T cells, we engineered CD4+ T cell-specific Hdac10 knockout (KO) mice (Hdac10fl/fl-CD4Cre) by crossing Hdac10fl/fl mice with CD4Cre mice (Figure S2 A), which were genotyped using PCR (Figure S2 B). The deletion of HDAC10 in CD4+ T cells was confirmed by western blotting (WB) and RT-qPCR (Figures S2 C and […]