Elucidating the therapeutic efficacy and mechanisms of arctigenin in ameliorating renal fibrosis: a combined transcriptomic and proteomic study
Ming An
BackgroundRenal fibrosis (RF) is a refractory disease characterized by excessive deposition of extracellular matrix, leading to tissue damage and scar formation. Fructus arctii (the dried ripe fruit of Arctium lappa L.) is a typical medicinal and edible plant widely utilized in both traditional medicine and culinary practices, rich in lignans, phenolic acids, and dietary fibers. Studies have shown that arctigenin (ATG), the main active component of F. arctii, possesses pharmacological effects in