Noncovalent PROTAC Antibody Drug Conjugates

Noncovalent PROTAC Antibody Drug Conjugates Krum, David Proteolysis Targeting Chimeras (PROTACs) are a new class of heterobifunctional drugs that induce proximity between an E3 ligase and a given protein of interest (POI), causing the POI to be ubiquitinated and targeted for proteasomal degradation. While the event-driven, irreversible pharmacodynamics of PROTACs offer advantages over traditional occupancy-driven small molecule inhibitors, their large molecular weight and existence outside of Li