Switchable annulation paths to diverse N-bridged bicyclic scaffolds via ligand-directed dicarbonylation

Nature Communications, Published online: 09 June 2026; doi:10.1038/s41467-026-74395-0 Existing synthetic approaches to 3-azabicyclo[3.2.0]heptane and 3-azabicyclo[3.1.1]heptane cores are typically restricted to single scaffolds, limiting scaffold diversity. Here, the authors report a ligandcontrolled, palladium-catalyzed tandem dicarbonylation of readily available cyclobutenols and amines, enabling divergent access to both 3-azabicyclo[3.2.0]heptane and 3-azabicyclo[3.1.1]heptane scaffolds from