The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport
Sergi Garcia-Manyes
Nature Physics, Published online: 30 April 2026; doi:10.1038/s41567-026-03242-2 The mechanical stability of proteins affects their import into the nucleus. Now it is shown that protein transport in and out of the nucleus depends on the local mechanostability of the protein cargo.