PATTY corrects open-chromatin bias for improved bulk and single-cell CUT&Tag profiling
Chongzhi Zang
Nature Communications, Published online: 22 May 2026; doi:10.1038/s41467-026-73599-8 CUT&Tag data can contain artifacts caused by open-chromatin bias. PATTY is a computational method that corrects this bias, enabling more accurate histone modification signal detection and single-cell clustering, improving epigenomics analysis.