Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8 + T cell-dependent tumor necrosis
Ryo Honda
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73300-z Many cancers depend on RAS signaling, but blocking diverse RAS mutants remains challenging. Here, authors engineer a protein-based pan-RAS inhibitor that induces tumor regression in mouse models and reveals an immune-dependent mechanism of action