Autophagy modulation in cancer
Lorenzo Galluzzi
Nature Reviews Drug Discovery, Published online: 18 May 2026; doi:10.1038/s41573-026-01449-9 Autophagy has a highly complex and context-dependent role in cancer, challenging the development of autophagy-modulating strategies. This Review discusses the potential of targeting autophagy to counteract malignant transformation, prevent disease progression and enable anticancer immunosurveillance. Existing and emerging pharmacological strategies and the associated limitations are critically presented.