Formononetin alleviated cisplatin-induced acute kidney injury by orchestrating renal tubular cell ferroptosis via PI3K/AKT/NRF2 pathway
Shan Mou
BackgroundCisplatin chemotherapy is limited by its nephrotoxicity, which leads to acute kidney injury (AKI). Ferroptosis is a key pathogenic mechanism in cisplatin-induced AKI. Formononetin (FN), a natural isoflavone, has demonstrated antioxidant and renoprotective potential, but its role in modulating ferroptosis remains unclear.MethodsA cisplatin-induced AKI model in mice and a cisplatin-injured HK-2 cell model were established. Kidney injury was assessed via serum creatinine, blood urea nitro