Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization
Bodong Wang
BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant-based foods and known for its potent antioxidant properties. Previous studies have shown that Dp3G suppresses oxidative stress and inflammation in atherosclerosis, protects against myocardial ischemic injury, and sensitizes glioblastoma to temozolomide by reducing drug resistanc