miR-21-5p attenuates hyperoxia-induced lung injury by modulating YAP1-dependent ferroptosis
Miao Chen
BackgroundHyperoxia-induced acute lung injury (HALI) is a frequent and clinically relevant complication of oxygen therapy in critically ill patients. Excessive oxygen exposure induces severe oxidative stress and alveolar epithelial cell (AEC) injury, yet the upstream regulatory mechanisms governing regulated cell death under hyperoxic conditions remain incompletely understood. Ferroptosis, an iron-dependent form of lipid peroxidation–driven cell death, has recently been implicated in HALI pathog