Protocol for a multicenter, randomized, single-blind, non-inferiority trial comparing nalbuphine hydrochloride versus hydromorphone hydrochloride for analgesia in mechanically ventilated ICU patients
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IntroductionDespite the established use of nalbuphine hydrochloride in anesthesia and obstetrics, high-quality evidence supporting its application in the intensive care unit (ICU) remains limited. This study aims to assess the efficacy and safety of nalbuphine hydrochloride for analgesia in ICU patients.MethodsThis is a multicenter, randomized, single-blind, parallel, positive control study. Eligible patients are randomly assigned to receive nalbuphine hydrochloride or hydromorphone hydrochlorid