Transfer RNA deacylases as beacons for non-canonical amino acid biosynthesis
Hung-wen Liu
Nature Chemistry, Published online: 23 April 2026; doi:10.1038/s41557-026-02139-0 Non-canonical amino acids are important building blocks for natural products but finding them is nontrivial. Now, transfer RNA deacylases have proved their utility as markers for biosynthetic gene clusters producing non-canonical amino acids, thereby accelerating the discovery of atypical natural products.