ROS-sensing transcription factor YchJ regulates RssB-RpoS pathway to protect Salmonella against oxidative attack by macrophages
Bingqing Li
Nature Communications, Published online: 12 May 2026; doi:10.1038/s41467-026-72842-6 In this work, the authors show that the uncharacterized protein YchJ acts as a ROS-sensing transcription factor in Salmonella; upon oxidation, YchJ dimerization represses rssB, stabilizing RpoS to activate antioxidant enzymes, protecting the pathogen from macrophage oxidative burst.