Are We Defining Treatment-Resistant Depression Correctly? Treatment-resistant depression (TRD) affects millions of people worldwide and represents one of the greatest challenges in modern psychiatry. Patients with TRD experience greater disability, poorer quality of life, higher healthcare utilization, and substantially increased... The post When Two Failed Antidepressants Are Not Enough: Rethinking Treatment-Resistant Depression appeared first on Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences .