Diabetes Care

OBJECTIVE To examine incidence of long-term complications among people with childhood-onset type 1 diabetes, focusing on age at diabetes onset. RESEARCH DESIGN AND METHODS A registry of children diagnosed with type 1 diabetes aged <16 years in New South Wales, Australia, between 1990 and 2009 linked to hospital, emergency department, public insurance, and death data from 2001 to 2019 to id…

OBJECTIVE To assess the prevalence of housing instability and its associations with cost-related nonadherence and financial toxicity among adults with uncontrolled diabetes. RESEARCH DESIGN AND METHODS We analyzed baseline randomized controlled trial data from 600 adults with uncontrolled diabetes and cost-related barriers to care. Logistic and linear regression assessed associations of housing i…

OBJECTIVE The association of gestational diabetes mellitus (GDM) subtypes with maternal cardiometabolic health is not known. We examined whether GDM subtypes were differentially associated with cardiometabolic health 10–14 years after delivery. RESEARCH DESIGN AND METHODS We used data from the prospective Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study. The exposure was GDM subtype (i…

OBJECTIVE: Neighborhood walkability is associated with lower gestational diabetes mellitus (GDM) risk, but its association with type 2 diabetes after GDM is unknown. We estimated this association and assessed effect modification by individual and neighborhood socioeconomic conditions. RESEARCH DESIGN AND METHODS: Women with GDM who delivered in New York City (NYC) in 2009-2011 were identified thr…

OBJECTIVE: Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subsequent diabetes risk across multiple ethnic groups. RESEARCH DESIGN AND METHODS: This retrospective cohort study include…

OBJECTIVE: To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines residual cardiovascular risk stratification. RESEARCH DESIGN AND METHODS: In this ancillary analysis of Bypass Angioplas…

OBJECTIVE: Islet autoantibody positivity (AB+) has not been evaluated across different race, ethnicity, and socioeconomic deprivation categories in individuals at risk for type 1 diabetes. We examined data from TrialNet of persons screened for ABs and evaluated patterns by race and ethnicity and socioeconomic deprivation. RESEARCH DESIGN AND METHODS: This analysis included 139,963 relatives of pe…

OBJECTIVE: Reduced microbial short-chain fatty acids (SCFA) have been implicated in type 1 diabetes (T1D) risk. We investigated fecal SCFA concentrations in mother-infant dyads from pregnancy to the onset of islet autoimmunity (IA) to test whether decreased fecal SCFA concentrations increase IA risk. RESEARCH DESIGN AND METHODS: Children with a first-degree relative with T1D and their mothers wer…

OBJECTIVE: Genetic variation in the glucagon-like peptide 1 receptor (GLP1R) has been implicated in type 2 diabetes (T2D) risk and treatment response. We investigated whether GLP1R R131Q, which was previously reported as a T2D-protective variant in genome-wide association studies, alters receptor signaling, β-cell function, and response to glucagon-like peptide 1 receptor agonists (GLP-1RAs). RES…

OBJECTIVE: To investigate the link between continuous glucose monitoring (CGM) metrics and risk of severe hypoglycemia and diabetic ketoacidosis (DKA) in individuals of type 1 diabetes. RESEARCH DESIGN AND METHODS: We pooled individual-level data from 10 studies of type 1 diabetes. From a 14-day baseline period, we derived CGM metrics (time in range [TIR] 70-180 mg/dL, time above range [TAR], tim…

BACKGROUND Prediabetes is a precursor of type 2 diabetes mellitus (T2DM), and lifestyle modifications are key preventive strategies. Primary care is central to prevention efforts, including screening, diagnosis, and follow-up. PURPOSE This systematic review and meta-analysis aimed to evaluate the effectiveness of lifestyle interventions delivered in primary care to patients at elevated risk of de…

OBJECTIVE Cystic fibrosis (CF)-related diabetes (CFRD) affects nearly half of adults with CF, but screening rates with the recommended oral glucose tolerance test (OGTT) are low. We evaluated the utility of a nonfasting, 50-g, 1-h oral glucose challenge test (GCT) as first-line screening for CFRD and pre-CFRD. The objectives were to define a cutoff that provides high sensitivity and reasonable sp…

OBJECTIVE Consensus guidelines recommend at least 14 consecutive days of continuous glucose monitoring (CGM) monitoring with 70% completeness to represent 90-day glycemic exposure. This study quantifies bias and uncertainty introduced into downstream analyses by using CGM metrics from incomplete or reduced monitoring, relative to a 90-day complete profile. RESEARCH DESIGN AND METHODS Using a type…

Although more evidence is needed, continuation of semaglutide after dialysis initiation appears safe and warrants efficacy testing regarding reduction in MACE and death.

T2D is associated with widespread changes in the circulating metabolome among adults in Mexico, reflecting diverse biological mechanisms and highlighting the importance of effective T2D management, including control of T2D-associated dyslipidemia, in this population.

Using Lyumjev in conventional CSII pump therapy provides more effective BRRs prior to exercise compared with Humalog, with fewer hypoglycemic events in active adults with type 1 diabetes.

CGM with RPM delivers superior health outcomes compared with SMBG and CGM and is likely cost-effective for patients with newly diagnosed type 1 diabetes. Despite higher intervention costs, CGM with RPM can reduce complications costs and generate net health care savings.