Frontiers in Chemistry

Antimicrobial depsipeptides and cyclodepsipeptides represent a structurally diverse class of natural products that have gained renewed attention as both antibacterial agents and molecular tools to interrogate bacterial physiology. Characterized by the incorporation of ester linkages within macrocyclic peptide frameworks, these molecules exhibit unique conformational properties that underpin disti…

The sluggish HER/OER kinetics and the lack of dependable, highly efficient electrocatalysts limit the large-scale use of electrochemical water splitting, despite its potential as a sustainable hydrogen generating technique. This review presents comprehensive and mechanistically informed evaluation of the advanced electrocatalysts with particular emphasis on non-noble metal-based systems, includin…

Introduction Accurate modeling of beta-decay energy spectra is essential for theoretical analysis and performance optimization in radioisotope energy conversion. Conventional parameterization methods may introduce fitting bias, while fixed-bandwidth KDE lacks local adaptability for asymmetric, multi-peak and long-tailed spectral distributions. Methods This study developed an Artificial Fish Swarm…

Cerium-based nanozymes (CeNZs) are a class of nanomaterials possessing enzyme-like catalytic activities. Their unique Ce 3+ /Ce 4+ redox pair and multi-enzyme mimicking activities make them highly advantageous for tumor chemodynamic therapy (CDT). This review systematically summarizes recent research progress in the application of CeNZs for tumor CDT. It focuses on their multi-enzyme catalytic me…

Introduction 3-Alkynyl-6-aryl-isothiazolo[4,3-b]pyridines have previously been shown to be potent inhibitors of the lipid kinase FYVE finger-containing phosphoinositide kinase (PIKfyve), displaying broad-spectrum antiviral activity. Methods To further study their structure–activity relationship (SAR), an efficient synthesis toward 3- bromo-5-chloro-isothiazolo[4,3-b]pyridine was established. It a…

In the present study, high-impact polystyrene (HIPS) nanocomposites filled with nano-silicon In the present study, high-impact polystyrene (HIPS) nanocomposites filled with nano-silicon particles (Si) and multi-walled carbon nanotubes (MWCNTs) were prepared, their structural, dielectric, and mechanical properties were investigated. X-ray diffraction (XRD) analysis confirmed the polycrystalline na…

These four articles collectively point to a core insight: chemistry is not merely a tool for biosensors, but rather their intrinsic determinant. The performance of each sensor -sensitivity, specificity, response speed, and stability-is ultimately governed by the controllability, reversibility, and efficiency of the underlying chemical reactions. More importantly, these studies all follow a simila…

Recently, green chemistry has attracted significant attention due to societal challenges regarding waste generation and energy consumption. Consequently, cross-dehydrogenative couplings (CDC) have emerged as a premier strategy for C–C bond formation. In this work, we report a novel organocatalytic cascade methodology based on the CDC activation of tetrahydroisoquinolines, followed by the formal a…

The increasing volume of road traffic, heavier axle loads on pavements and extreme weather events have exposed the limitations of conventional asphalt pavements, particularly susceptibility to rutting, thermal cracking, and rapid aging [1,2], so that better performance of road construction materials are required.Despite their widespread use and despite the relatively low cost, conventional unmodi…

This study investigates phosphate adsorption using exfoliated serpentinite produced by intercalation with potassium nitrate (KN/SP), urea (U/SP), and potassium acetate (KC/SP), with emphasis on performance, mechanism, and realistic applicability. All modified adsorbents showed strongly improved phosphate uptake, reaching maximum capacities of 127.85 mg g -1 (KN/SP), 154.18 mg g -1 (U/SP), and 183…

Covalent-organic frameworks (COFs) and metal-organic frameworks (MOFs) have been a promising carrier for drug delivery because of excellent biocompatibility, developed porous structure and sufficient interactions of host-guest molecules. This paper mainly reviews latest research progress of COFs and MOFs including their synthesis approaches and applications in drug delivery. Specifically, COFs as…

Over the past decade, significant progress has been made in the study of pillar [n]arenes; however, the development of their analogs remains underexplored, offering new opportunities for the discovery of functional materials. In this work, a luminescent thiophene-extended pillar [6]arene ( TPExP6 ) featuring a π-rich cavity was designed and synthesized from 2,5-dibromothiophene and (4-formylpheny…

Among the methods of temperature measurement, luminescent thermometry has recently become increasingly interesting due to a number of advantages over traditional thermometers such as high sensitivity and spatial resolution, no need for contact with the analyzed object, and the capability for remote monitoring of temperature fields in complex conditions. Despite the obvious advantages, the practic…

Introduction Gouty arthritis is characterized by the deposition of monosodium urate crystals, which drive not only joint inflammation but also progressive bone erosion and structural damage. Existing therapeutic strategies remain limited by poor local bioavailability and inadequate protection of bone tissue. Hydrogel drug delivery systems offer significant potential for localized gout therapy. Ho…

Nucleophilic fluorination of a sterically hindered cyclopentanone intermediate under microwave irradiation is established to construct the key 6′,6′- gem -difluorocarbocyclic scaffold, which provides a practical approach to the synthesis of 6′,6′- gem -difluorinated carbocyclic nucleosides. The requisite cyclopentanone was accessed through the optimized oxidative cleavage of a methylenecyclopenta…

Silyl-based tridentate ligands [SiL 2 ] n− (n = 1, 2; L = PR 3 , NR 2 or other groups) have emerged over the last decades as a versatile class of ligands for transition metal (TM) chemistry. TM–(κ 3 - Si , L 2 ) complexes display unique structural features and reactivity that arise directly from the incorporation of a strongly σ-donating silyl group into the pincer ligand framework. While most st…

Tobacco is a globally cultivated crop featuring distinct quality variations among leaves from different geographical origins. To develop a rapid, robust, and accurate method for multi-origin traceability, this study employed near-infrared spectroscopy combined with rapid chemical composition analysis to obtain 70 chemical components in samples from nine major tobacco-producing regions in China an…