Synthesis and host-guest chemistry of a thiophene-extended pillar[6]arene: toward applications in nitroaromatics removal and cell imaging

Over the past decade, significant progress has been made in the study of pillar [n]arenes; however, the development of their analogs remains underexplored, offering new opportunities for the discovery of functional materials. In this work, a luminescent thiophene-extended pillar [6]arene ( TPExP6 ) featuring a π-rich cavity was designed and synthesized from 2,5-dibromothiophene and (4-formylphenyl)boronic acid via a five-step procedure with an overall yield of approximately 9.8%. This molecule c