Formal organocatalytic fluoronitromethane addition to tetrahydroisoquinolines through a CDC process

Recently, green chemistry has attracted significant attention due to societal challenges regarding waste generation and energy consumption. Consequently, cross-dehydrogenative couplings (CDC) have emerged as a premier strategy for C–C bond formation. In this work, we report a novel organocatalytic cascade methodology based on the CDC activation of tetrahydroisoquinolines, followed by the formal addition of fluoronitromethane. The reaction is catalyzed by organic dyes (Rose Bengal) using green LE