Journal of Ovarian Research

Platinum-resistant ovarian cancer (PROC) has a poor prognosis and limited treatments. Relacorilant plus nab-paclitaxel (RnP) shows clinical efficacy in Phase III trials, but its cost-effectiveness has not yet been evaluated. This study evaluated RnP versus nab-paclitaxel (nP) for PROC from the U.S. payers’ perspective. A partitioned survival model (1-month cycle, 5-year time horizon) was utilized…

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance, which synergistically disrupt the ovarian microenvironment. This pathological interplay induces chronic inflammation, oxidative stress, and metabolic dysregulation, subsequently triggering aberrant activation of multiple forms of programmed cell death (PCD) in granulosa cells, including apoptosis, pyropt…

Platinum-based chemotherapy is the standard treatment for ovarian cancer. However, the emergence of platinum resistance greatly limits its effectiveness. Investigating novel therapeutic strategies to overcome platinum resistance is imperative to extend survival in ovarian cancer patients. The cytotoxic effects of CC223 on SKOV3DDP and A2780DDP were evaluated using the CCK8 assay. Based on the ova…

Trends toward earlier age at menarche, the starting point in women’s reproductive lifespan, have been observed globally. Whether an earlier age at menarche influences Anti-Müllerian hormone (AMH), a clinical indicator of ovarian reserve, remains unclear due to a lack of community-based data. This nationwide cross-sectional survey was carried out in China’s 15 provinces from May 2019 to April 2021…

Ovarian cancer (OC), a prevalent malignancy of the female reproductive system, is significantly impacted by drug resistance, which reduces treatment efficacy and worsens patient survival. Therefore, identifying broader therapeutic targets is crucial for improving treatment outcomes in OC patients. The research project utilized Mendelian randomization (MR) analysis and summary data-based Mendelian…

Emerging evidence suggests that ferroptosis resistance contributes to the ovarian cancer (OC) carcinogenesis. Here, the study identified a tumour promoting factor FSP1 and investigated the role of Salidroside in OC ferroptosis resistance. In vitro, Salidroside alleviated the ferroptosis resistance of OC cells, and promoted the ferroptosis features. In vivo, Salidroside could inhibit OC growth and…

Human preantral follicle development requires finely tuned signaling between oocytes and granulosa cells, supported by a structured extracellular matrix (ECM). This study investigates how follicle-stimulating hormone (FSH) and growth differentiation factor 9 (GDF-9), alone or combined, influence follicular growth and ECM organization in a 3D cell culture system. All culture conditions maintained …

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and metabolic dysregulation. Emerging evidence suggests a significant role of gut microbiota in its pathophysiology. This study explores the composition of the gut microbiota in PCOS patients versus Non-PCOS and its correlation with hormonal levels to understand its potential impact on PCOS. In…

To investigate the role of centrin-2 (CETN2) in platinum resistance and its underlying mechanisms in ovarian cancer. We conducted a pan-cancer analysis of CETN2 expression and its associated genes using the STRING and TIMER databases. Data from the GEO and TCGA databases were employed for survival, clinical correlation, and prognostic analyses. Enrichment and co-expression analyses were performed…

It is becoming more well acknowledged that oxidative stress is a crucial component that connects the hormonal, metabolic, and reproductive aspects of polycystic ovarian syndrome (PCOS). A more holistic and natural approach to managing the illness might be possible through lowering this disparity. This review outlines new findings about the effects of dietary antioxidants on critical processes rel…

Ovarian cancer is one of the deadliest gynecological malignancies, mainly because of its silent development and the lack of effective conventional methods for diagnosis. Because of their extraordinary stability in bio fluids and expression signatures that specifically correlate with tumors, circulating microRNAs (miRNAs) have received much attention as non-invasive diagnostic biomarkers. This met…