Assessing diagnostic accuracy of circulating microRNAs as biomarkers for ovarian cancer: a systematic review and meta-analysis

Ovarian cancer is one of the deadliest gynecological malignancies, mainly because of its silent development and the lack of effective conventional methods for diagnosis. Because of their extraordinary stability in bio fluids and expression signatures that specifically correlate with tumors, circulating microRNAs (miRNAs) have received much attention as non-invasive diagnostic biomarkers. This meta-analysis evaluates the diagnostic value of circulating miRNAs for early ovarian cancer. A systemati