Bioinformatics and clinical analysis of CETN2’s impact on platinum resistance and prognosis in epithelial ovarian cancer

To investigate the role of centrin-2 (CETN2) in platinum resistance and its underlying mechanisms in ovarian cancer. We conducted a pan-cancer analysis of CETN2 expression and its associated genes using the STRING and TIMER databases. Data from the GEO and TCGA databases were employed for survival, clinical correlation, and prognostic analyses. Enrichment and co-expression analyses were performed to identify relevant pathways and genes. We also analyzed the tumor microenvironment, immune checkpo