Identification of DHX58 as a potential therapeutic target for ovarian cancer through multi-omics Mendelian randomization and transcriptomic data analysis

Ovarian cancer (OC), a prevalent malignancy of the female reproductive system, is significantly impacted by drug resistance, which reduces treatment efficacy and worsens patient survival. Therefore, identifying broader therapeutic targets is crucial for improving treatment outcomes in OC patients. The research project utilized Mendelian randomization (MR) analysis and summary data-based Mendelian randomization (SMR) to identity potential treatment targets for OC. The eQTLGen collaboration provid