BMC Infectious Diseases

Abstract Background Tuberculosis (TB) remains a leading cause of global mortality, underscoring the need for accessible prognostic tools. C-reactive protein (CRP) is a widely available acute-phase biomarker that may predict outcomes in TB. This systematic review and meta-analysis assessed the prognostic value of baseline CRP in predicting mortality among adults with TB. Methods Eligible studies i…

Helicobacter pylori is a globally prevalent chronic bacterial infection, disproportionately affecting low- and middle-income countries. Despite its significant gastrointestinal burden, epidemiological data from Afghanistan are limited. This study aimed to determine the prevalence, infection status, and associated factors of H. Pylori among adult dyspeptic patients in Jalalabad. A cross-sectional …

The three components of the platelet-albumin-bilirubin (PALBI) score are closely related to inflammatory responses, hepatic dysfunction, and coagulation abnormalities in sepsis, but its prognostic significance in this population remains unclear. This study aimed to examine the association between PALBI score and 30-day in-hospital mortality in patients with sepsis. Data from the Medical Informati…

Herpes zoster (HZ) and postherpetic neuralgia (PHN) cause substantial clinical and economic burdens, especially in older adults, yet real-world data from China are limited. Using the Jinan Regional Health Information Platform, we conducted a population-based retrospective cohort study (2018–2023) to estimate HZ and PHN incidence (per 1,000 person-years [PY]), recurrence rates, and direct medical …

Despite guideline-mandated universal screening, adherence to hepatitis B virus (HBV) testing before the initiation of biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) remains suboptimal, placing patients at risk for HBV reactivation (HBVr). We retrospectively studied 1,909 adults starting b/tsDMARD therapy from 2004 to 2024, comparing three stages: baseline (200…

This study aimed to construct and validate a nomogram to predict the long-term incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) and metabolic dysfunction (MD) receiving antiviral therapy. 809 individuals with hepatitis B combined with metabolic dysfunction who received antiviral therapy between 2009 and 2023 were randomly assigned to the training and validati…

This study aimed to evaluate the seroprevalence of anti-IgG antibodies against Rickettsia typhi among patients with unexplained acute fever (UAF) at the Sourô Sanou University Hospital (CHUSS) in Bobo-Dioulasso, Burkina Faso. A prospective study was conducted from July to October 2025. A total of 87 patients with UAF were enrolled. The diagnostic protocol systematically included blood cultures an…

Cavernous sinus thrombophlebitis (CST) is a rare, life-threatening infection. Its management becomes exceptionally challenging when complicated by intracranial abscesses, hydrocephalus, and multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). A 52-year-old woman with poorly controlled diabetes presented with headache, eye pain, diplopia, fever, and progressive…

Sepsis and septic shock are leading causes of intensive care unit (ICU) mortality, with persistent high mortality despite standard care including norepinephrine. This study aimed to investigate whether early combination therapy with norepinephrine and esmolol improves hemodynamics and 28-day survival in septic shock patients. This retrospective cohort study enrolled patients with septic shock bet…

To investigate the clinical characteristics and risk factors of invasive pulmonary aspergillosis (IPA) in patients with severe fever with thrombocytopenia syndrome (SFTS). We conducted a retrospective analysis of 136 SFTS patients hospitalized at Zhongnan Hospital of Wuhan University between January 2017 and May 2024. Patients were stratified into IPA (n = 33) and non-IPA (n = 103) groups. Demogr…

This study aims to investigate the association between the Red cell distribution width to platelet count ratio (RPR) and adverse outcomes in critically ill patients with sepsis-induced coagulopathy (SIC). Clinical data from 7,014 patients admitted to the Intensive Care Unit (ICU) with SIC were extracted from the MIMIC-IV (3.1) database. The study population was divided into four groups based on q…