European journal of medical research

Abstract Objective This study aimed to develop and validate risk prediction models for postoperative pneumonia (POP) in osteosarcoma (OS) patients using multiple machine learning (ML) algorithms, ultimately selecting the model with optimal predictive performance for risk assessment. Methods A retrospective analysis was performed on the clinical data from 290 patients with OS who underwent surgica…

To investigate the relationship between cerebral microbleeds (CMBs) and interstitial fluid (ISF) content in white matter and to statistically assess whether impaired visibility of deep medullary vein (DMV) is associated with this relationship. Clinical and multimodal magnetic resonance imaging (MRI) data were obtained from 150 patients admitted to a neurology department. DMV visibility and integr…

Diabetic kidney disease (DKD) is the most severe microvascular complication of diabetes and a major cause of end-stage renal disease; however, its pathogenesis remains incompletely understood. Cuproptosis, a recently identified type of copper-dependent cell death, provides a novel perspective for exploring the mechanisms underlying DKD. This study aimed to investigate the role of cuproptosis-rela…

The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) has emerged as a promising lipid predictor for various cardiovascular conditions. However, its role in predicting long-term outcomes after coronary artery bypass grafting (CABG), particularly in multivessel disease (MVD) patients, remains unclear. We conducted a retrospective study of MVD patients wh…

To investigate the roles of the mechanically-sensitive channel Piezo1 and the inflammatory factor IL-6 in cervical spondylotic radiculopathy (CSR) pain and the mechanism between them. The CSR model in SD rats was established by nerve injury caused by steel needle compression. Immunocytochemistry, double-fluorescence labeling and behavioral tests were used to analyze the expression and co-localiza…

Sorafenib (SOF) exhibits broad-spectrum antitumor activities in human cancers, including colorectal cancer (CRC). SOF-associated drug resistance and side effects largely limit its clinical application. Tumor-associated macrophages (TAMs) play pivotal roles in the progression and chemoresistance of CRC. Presently, we focus on the functions and mechanisms by which NOTCH4 affects SOF sensitivity in …

Pulmonary cavitation is a characteristic feature of severe tuberculosis (TB) that substantially influences both disease transmission and clinical outcomes. Although immunonutritional imbalances have been implicated in the pathogenesis of TB, the role of composite biomarkers, such as the neutrophil-to-albumin ratio (NAR), in pediatric populations has not been extensively investigated. This study s…