Effects of Piezo1/IL-6 on radicular pain in cervical spondylotic radiculopathy

To investigate the roles of the mechanically-sensitive channel Piezo1 and the inflammatory factor IL-6 in cervical spondylotic radiculopathy (CSR) pain and the mechanism between them. The CSR model in SD rats was established by nerve injury caused by steel needle compression. Immunocytochemistry, double-fluorescence labeling and behavioral tests were used to analyze the expression and co-localization of Piezo1 and IL-6. Interventions were carried out using Yoda1 (Piezo channel activator) and and