Novel cuproptosis-related genes as predictors of diabetic kidney disease: bioinformatics and experimental validation
Qian Wang·Ying Li·Yanqing Chi·Tao Zhang·Min Li·Ke Yu·S P Zhao·Lu Bai·Canghui Guo·Maodong Liu·Yongzhe Chen
Diabetic kidney disease (DKD) is the most severe microvascular complication of diabetes and a major cause of end-stage renal disease; however, its pathogenesis remains incompletely understood. Cuproptosis, a recently identified type of copper-dependent cell death, provides a novel perspective for exploring the mechanisms underlying DKD. This study aimed to investigate the role of cuproptosis-related genes (CRGs) in DKD and identify potential diagnostic markers. We integrated renal tubule gene ex