NOTCH4 downregulation repolarizes tumor-associated macrophages and enhances the sorafenib sensitivity of colorectal cancer cells

Sorafenib (SOF) exhibits broad-spectrum antitumor activities in human cancers, including colorectal cancer (CRC). SOF-associated drug resistance and side effects largely limit its clinical application. Tumor-associated macrophages (TAMs) play pivotal roles in the progression and chemoresistance of CRC. Presently, we focus on the functions and mechanisms by which NOTCH4 affects SOF sensitivity in CRC and TAM-mediated immunosuppressive tumor microenvironment (TME). Here, we found that NOTCH4 overe