Sex-specific differences in the efficacy and prognosis of 5-aminosalicylic acid therapy for ulcerative colitis: A 20-year retrospective cohort study

BACKGROUND Despite 5-aminosalicylic acid (5-ASA) being the first-line therapy for ulcerative colitis (UC), there is limited real-world evidence concerning sex-specific differences in the efficacy of 5-ASA therapy and patient prognosis. AIM To investigate sex-disparities in 5-ASA treatment responses and long-term outcomes in a Chinese large-scale UC cohort. METHODS A retrospective study was conducted on 554 consecutive UC patients treated with 5-ASA at Peking Union Medical College Hospital betwee