Editorial: The role of innate immunity in the pathogenesis of autoimmune and autoinflammatory diseases

Historically, research on autoimmune diseases has primarily emphasized adaptive immunity. However, this perspective is increasingly recognized as insufficient, as it does not fully capture the complexity and heterogeneity of immune-mediated disorders. The articles in this Research Topic collectively support a conceptual shift that positions innate immunity as a key player of disease initiation, amplification, and tissue injury. Despite employing diverse methodologies, including mechanistic studi