80,000 Hours

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What does it really take to lift millions out of poverty and prevent needless deaths? In this special compilation episode, 17 past guests — including economists, nonprofit founders, and policy advisors — share their most powerful and actionable insights from the front lines of global health and development. You’ll hear about the critical need to boost agricultural productivity in sub-Saharan Afri…

I’ve spent years calling for more government oversight of frontier AI development. So am I a hypocrite for opposing the Pentagon’s attempt to commit “corporate murder” against Anthropic? That’s what I’ve heard. As venture capitalist Marc Andreessen put it on Twitter: “Every single person who was in favor of government control of AI, is now opposed to government control of AI.” It’s a natural way …

Richard Moulange: What the team were able to do was they had the base Evo 2 model, and then they fine-tuned it on what are called bacteriophages — so these are viruses that eat, that kill bacteria — fine-tuned it on something like 15,000 of those, and then started prompting it with the beginnings of known bacteriophage genomes to see if they can make new ones. So this is again akin to, with LLMs,…

Rob Wiblin: Your most recent piece, “Europe’s next war: The rising risk of a NATO–Russia conflict,” argues that the risk of a direct NATO–Russia confrontation could actually be higher after a ceasefire in Ukraine — which I think to many people will seem kind of counterintuitive. It’s somewhat counterintuitive to me. So let’s start with a big-picture question: How seriously should we take the risk…

Review status Based on a medium-depth investigation Table of Contents Politics can feel intractable. Many people doubt that they have any chance of individually influencing outcomes in a system this large. We think this is too pessimistic. Fundamentally, while your odds of changing an election’s outcome will often be modest, the huge potential impact makes it worth trying. Attempting ambitious pl…

Our version of the Sable story differs from the book in a number of ways. Most of our changes were made for one of two reasons: - Simplicity. We had to tell the story within a 40-minute video that also covered the book’s core arguments. We chose to simplify or eliminate several plot points as a result (in Yudkowsky & Soares’ story, for example, Sable is assigned a large suite of math problems, an…

An overarching question that matters for governance of artificial intelligence is how much we can trust technology companies to do the right thing in cases where it becomes seriously costly for them to do so. Well, some internal documents leaked from Meta (the company behind Facebook, Instagram, and WhatsApp) are a really important piece of evidence in this debate — and one that, in my opinion, f…

Zershaaneh Qureshi: Right. OK, so there are at least three kinds of dynamics that seem worrying: one is active power grabs, one is the way that the distribution of wealth gets reshaped and these other economic factors, and one is this sort of broad category of things you’re calling “epistemics” — our ability to make sense of things and predict what might happen next and react appropriately and so…