Modular, automated flow synthesis of spirocyclic tetrahydronaphthyridines from primary alkylamines

Curious how far automated Flow Chemistry can go? Read this Nature.com paper… We are pleased to share that the Cresswell Group, led by Dr Alexander J. Cresswell at the University of Bath (UK), have demonstrated the synthesis of a number of spirocyclic tetrahydonaphthyridines (THNs) expanding the chemical space of these important scaffolds for drug discovery. Presented at the recent Automated Synthesis Forum in Oxford, UK, the group are using a combination of photochemistry with Flow Chemistry to.