Cancer clones- mixing and spreading
Catherine Potenski
The trajectory of tumor cells during metastasis can be influenced by many factors, including the physical environment and the genetic makeup of metastatic clones. In high-grade serous ovarian cancer, there are limited barriers in the intraperitoneal space, allowing for extensive spreading and mixing of tumor cells. A recent article published in Nature Genetics explores these different patterns of clonal evolution in metastatic ovarian cancer using a combination of bulk and single cell sequencing