Supercoiling as a regulator: the role of biophysical feedback in transcription and chromatin dynamics

Supercoiling as a regulator: the role of biophysical feedback in transcription and chromatin dynamics Johnstone, Christopher P. Transcription induces a wave of DNA supercoiling, altering the binding affinity of RNA polymerases and reshaping the biochemical landscape of gene regulation. Instead of transcription being a simply biochemical progress acting over a static energy landscape, this supercoiling diffuses outward, dynamically reshaping the regulation of proximal genes and forming a complex