Purine salvage pathway protects CD8 + T cells from metabolic stress
Sidonia Fagarasan
Nature Immunology, Published online: 13 April 2026; doi:10.1038/s41590-026-02491-w Tajima et al. show that a transient or continuous high-fat diet induces metabolic changes in CD8+ T cells that lead to increased vulnerability to ferroptosis and reduced antitumor responses.