Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges
Edward F. Chang
Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02258-4 High-density single-neuron recordings in patients with epilepsy revealed interictal discharges are generated by structured laminar circuits. These circuits overlapped with cognitive circuits and could predict discharges up to 1 s in advance.