Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders
Brian J. Bacskai
Nature Reviews Neuroscience, Published online: 26 March 2026; doi:10.1038/s41583-026-01032-6 Astrocytic Ca2+ signalling is a fundamental and highly spatiotemporally nuanced mechanism for maintaining brain homeostasis. In this Review, Bacskai and colleagues discuss how astrocytic Ca2+ homeostasis is altered in ageing and neurodegenerative diseases and plays a central role in neurodegenerative pathophysiology.