Realizing the promise of CAR-T cell therapies for autoimmune diseases
Raphaël Ognar
Nature Reviews Drug Discovery, Published online: 17 April 2026; doi:10.1038/d41573-026-00062-0 Initial clinical data indicate that CAR-T cell therapies that deplete B cells could change the treatment paradigm in refractory B cell-driven autoimmune diseases. This article discusses key considerations in realizing the potential of such therapies.