Nature Communications, Published online: 11 June 2026; doi:10.1038/s41467-026-74063-3 Traditional strategies to address wear particle-induced osteolysis largely focus on reducing wear generation, rather than mitigating the immunostimulatory effects elicited by wear particles. Here, the authors report a proactive preventive approach to implant design that adopts CeO2 nanozymes-incorporated liners to actively limit the harmful immune effects of particles.