Unraveling how electrostatic gradients manifest in electrophsiological assays

The Journal of Physical Chemistry B published “From Flux to Function: Extracting Mechanistic Insights from Ion Channels via I–V and I–μ Analyses” by Hannah Weckel-Dahman, Ryan Carlsen, Alexander Daum, and Jessica M. J. Swanson The molecular origins of ion-channel current–voltage (I–V) relationships are often unclear, obscured by ensemble averaging in experimental analysis and persistent underestimation of single-channel ion currents in simulations. Here, we present a mathematical framework that.