Cytosolic CTH senses bacterial lipoproteins and drives noncanonical inflammasome activation
Pengyan Xia
Nature Immunology, Published online: 30 April 2026; doi:10.1038/s41590-026-02511-9 Xia and colleagues show that CTH, an enzyme involved in the metabolism of sulfur-containing amino acids, hydrolyzes cytoplasmic bacterial lipoproteins and triggers the formation of molecular structures that can activate caspase-11.