Total syntheses of (+)-dalesconols A and B enabled by triple-relayed remote chirality transfer
Xinjun Luan
Nature Communications, Published online: 21 May 2026; doi:10.1038/s41467-026-73353-0 Natural products with densely fused polycyclic frameworks, such as dalesconols A and B, pose longstanding challenges for asymmetric synthesis due to their intricate stereochemistry. Here, the authors report concise, enantioselective total syntheses via a triple-relayed remote chirality transfer strategy using palladium/norbornene catalysis.