Discovery of novel biomarkers associated with myocardial fibrosis in chimpanzees (Pan troglodytes)
Melissa M. Grant
BackgroundIdiopathic myocardial fibrosis (IMF) is a prevalent and life-threatening condition in captive chimpanzees (Pan troglodytes). Ante-mortem diagnosis remains challenging due to the limitations of current veterinary diagnostics. This study aimed to identify and validate circulating serum protein biomarkers for the detection of IMF.MethodsSerum samples collected from zoo-housed chimpanzees with post-mortem confirmed cardiac phenotypes were utilized. An initial discovery phase using a Proxim