Altered perivascular-aligned diffusivity in postherpetic neuralgia assessed by the DTI-ALPS index
Kang Min Park
BackgroundThe glymphatic system has been proposed as a key pathway for interstitial fluid clearance in the brain, but its role in chronic neuropathic pain conditions such as postherpetic neuralgia (PHN) remains unclear. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index has been suggested as a noninvasive proxy of perivascular-aligned diffusivity related to glymphatic-associated processes.MethodsA total of 83 participants were recruited, comprising 42 patients with