Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity
Qun-Ying Lei
Nature Immunology, Published online: 14 April 2026; doi:10.1038/s41590-026-02484-9 Here the authors identify a tumor immunoevasion mechanism in which tumor cells release branched-chain amino acid metabolites that can bind and activate Notch on tumor-associated macrophages, reprogramming these cells to be immunosuppressive.