BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition
Harinder Singh
Nature Immunology, Published online: 20 April 2026; doi:10.1038/s41590-026-02495-6 Singh and colleagues identify a role for the transcription factor BLIMP1, encoded by Prdm1, in the regulation of germinal center responses. They show that BLIMP1 acts as a negative feedback regulator of B cell affinity maturation and clonal dominance.