Glucocorticoids injure the airway epithelial barrier via endoplasmic reticulum stress-related apoptosis in asthma
Chao Niu
IntroductionGlucocorticoids serve as the first-line clinical treatment for asthma; however, 5%–10% of asthma patients respond poorly to glucocorticoids, and their underlying mechanism remains unclear. We investigated whether glucocorticoids can induce airway epithelial endoplasmic reticulum (ER) stress-related apoptosis to decrease their efficacy in treating asthma.MethodsWe established a BALB/c mouse model of OVA-induced asthma and treated the mice with the glucocorticoid dexamethasone. H&E