De novo design of DNA origami with a generative diffusion model
Do-Nyun Kim
Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73578-z AI-based inverse design of DNA origami has been limited by the scarcity of large, standardised datasets. Here, the authors present a diffusion-based design framework trained on simulated equilibrium conformations, highlighting the promise of generative AI models empowered by physical simulation for de novo design of DNA origami.