Cortical evolution, ZBTB18, and more
Jill Adams
Brain evolution: Molecular and cellular regulatory components that support neuronal communication across the layers of the cerebral cortex distinguish mammalian brains from non-mammalian ones, a new study details. The investigators focused on the many types of excitatory projection neurons and their genes—and specifically zeroed in on the transcription factor ZBTB18, which is implicated in autism and intellectual disability. Deletion of ZBTB18 in mouse excitatory projection neurons decreased...